WOW! I had know of their restaurant before I moved to the area. Finding out I was just down the street made this a 'must try!' Not one disappointed expectation. Walking in you are welcomed into a mix of Buffalo pride meets Mafia nostalgia. We checked out the menu which wasn't too big or too small. We settled on large cheese pizza and wings. A reasonable 20 min wait. We sat and took in all the pictures, I was drawn to a large article on the wall that spoke of a great storm that wrecked the area and this was the only pizza place to stay open (there are many pizza places here lol) we played an old school arcade game they had in the front window, before we knew it our food was up. A very pleasant staff reviewed our order completely making sure we got a peek at our pizza to make sure it was cooked to our taste (this goes a long way with me! A restaurant that isn't afraid to show you what they put in the box tells me they are confident in making sure I'm satisfied) we got home and the pizza was just as good as it looked. I was impressed the cheese was real mozzarella and I could immediately that it was fresh. Overall just a great experience!

Fresh and Hot. Sauce is on the sweeter side, not overpowering pairs excellently with the crust Underneath the cheese and sauce the slice is soft at first almost a pillowy texture and ends in a perfect bite thanks to the nice golden crisp on the bottom. Could of used a little more cheese to the edge of the crust, but plenty throughout. Sausage was typical sausage for pizza. It will satisfy your pizza munchie craze hands down. Overall the experience was great. Pizza was incredible however I wish the cheese reached the edge, personal preference i know. I didn't take off points for it though. We dined outside. Very nice view on Seneca street. We even gave a random individual our last two slices and noticed when we were pulling away he had a huge smile on his face and must of enjoyed it as much as we did. Pizza Rating 8.5 ****Update**** Here again at Wiseguys....my review hasnt changed. Sauce is impeccable. Pizza has a very good bite and crisp to it as always. #1 in South Buffalo. Go Bills

This is by far some of the best pizza I've ever had in Buffalo.

Extremely good food , flavorful and packaging . I would totally recommend this to people. The pizza is a nice sweet sauce and cheesy . I ordered off door dash . Prices back up the amount of food you get . I'll be back .

I ordered delivery via the Slice app. I had heard great things. It took about an hour. The chef salad is enormous. Gluten free white pizza is surprisingly delicious. Regular crust veggies pizza also amazing. My only complaint would be they weren't exactly hot but that's fine. Will Def order again.

The food was fantastic. Pies baked to perfection and delivered with care. The staff went above and beyond to be sure I was taken care of... Thank you. It was a fantastic meal and would recommend to anyone who wants thick crust that is baked golden crispy, smothered in toppings with a sweet and tangy sauce to die for.

Have enjoyed Buffalo-style pizza all my life and have been trying out some of the less widely-known neighborhood places. Of course Buffalonians know about Bocce’s, La Nova, Imperial, Santora’s and others, and there are also many other great places you should try for new experiences, and to support these local gems, as well. I had pizza and wings tonight at Wise Guys Pizza in South Buffalo on Seneca Street - and both were GREAT! As a first-timer, I was made very welcome. I wish I had asked for the name of the young lady who took my order, but she was very nice and went out of her way to make sure I had everything I needed. It’s so great to see people who are kind and enjoy their jobs and are really great and friendly with customers. When my food was ready, I decided to eat there. Why not eat it right out of the oven?!? The pizza was Buffalo-Style at its finest - and they were not chincy on the ingredients. More cheese than most of the bigger places and lots of cup-and-char pepperoni, too. The wings were good, meaty and I had them crispy, because that’s how I like ‘em. It was fun just people-watching as neighborhood people strolled in and out with their food. Everyone was smiling and friendly. This neighborhood didn’t seem to have gotten the memo that everyone needs to be angry these days. This part of South Buffalo has a great vibe with lots of activity and many businesses operating quite successfully. Buffalo people generally like to stay within their basic neighborhoods/areas, but if you’re not from South Buffalo - make it an adventure and see a great place and well-kept secret. Head to Wise Guys - and take a look at this well-preserved and loved section of Buffalo. You’ll be glad you did - and you’ll love the pizza!

They show up when they say they will. Prices are fair. The wings are always crunchy there never squishy. Since moving to buffalo from Rochester it's been a struggle to find a decent Pizza and wing place. There's less than 5 places in the entire city of Buffalo that I would recommend to anyone and this place is one of them!